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Our Pipelines

Calviri is creating technically and clinically integrated pipelines of diagnostic tests and cancer vaccines for both dogs and humans.

Diagnostic Pipeline

Canine Multi-Cancer Early Detection (MCED) Test
Human Multi-Cancer Early Detection (MCED) Test
Human Stage 1 Breast Cancer Diagnostic Test
Human Predictive Diagnostic for Response to Checkpoint Inhibitors

Fusing Biology 
with Microchip Technology

Calviri has learned to make semiconductor chips that query cancer biology 

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Vaccine Pipeline

Canine Preventative Vaccine
Canine Hemangiosarcoma (HSA) Therapeutic Vaccine
Human Neurofibromatosis Type 1 (NF-1) Therapeutic Vaccine
Human Renal Medullary Carcinoma (RMC) Therapeutic Vaccine
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Our Clinical Trials

Calviri is actively engaged in canine and human clinical trials to evaluate our therapeutic and preventative vaccines.

First Ever Preventative Cancer Vaccine Trial

Calviri announced the successful conclusion of the Vaccine Against Canine Cancer Study (VACCS) on May 4, 2024; a five-year clinical trial investigating a novel preventative cancer vaccine in dogs. This multi-center, double-blinded, placebo-controlled study- the largest of its kind in veterinary oncology- represents a significant milestone in the fight against canine cancer. 

Canine Clinical Trials

Canine Clinical Trials

Preventative Cancer
(VACCS) Trial

We have shown REDNs are strong immunogens and have anti-tumor effects as vaccines in mouse models (Shen et. al. Sci. Rep. 2019). Based on this preclinical demonstration of REDN utility, we used our Discovery chips to select and design a pre-made, REDN vaccine to prevent canine cancer. We initiated a research trial in 2019 with 800+ owner-enrolled dogs. Safety review boards found no side-effects. This trial was completed in May 2024.  Results are being analyzed for publication.  

Hemangiosarcoma (HSA)
Therapeutic Trial 

Serum samples from dogs diagnosed with early-stage HSA were collected. These samples were queried on our REDN Discovery chips for optimal components to include in a pre-made, therapeutic vaccine against early-stage disease. REDN’s have been selected; vaccine has been produced and vialed. Vaccinations are readied. 

Multi-Cancer
Therapeutic Trial 

Serum samples from dogs diagnosed with one of 5 different early-stage cancers were collected. These are being evaluated on our Discovery chips for cancer-specific REDN binding activities. Results will be used to select REDN’s to compose a pre-made multi-cancer vaccine. 

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Off-The-Shelf Vaccines

Both our preventative and therapeutic vaccines are pre-made and ready to take off the shelves. These vaccines are possible because we have discovered a plentiful source of immunogenic neoantigens that are shared among patient tumors.  

Human Clinical Trials

Human Clinical Trials

Renal Medullary Cancer (RMC) Therapeutic Trial 

People, especially athletic young men with sickle-cell trait, are predisposed to RMC. Our first-in-man, two-armed trial will enroll those diagnosed with disease and healthy sickle-cell carriers. Samples have been collected in partnership with collaborators at MD Anderson Cancer Center. These will be evaluated on our REDN Discovery chips to identify RMC-specific neoantigens as components for the vaccine. 

Neurofibromatosis (NF-1) Pediatric Therapeutic Trial 

Children with a NF-1 genetic condition have a high risk of suffering several different malignant cancers, most frequently gliomas. Our two-armed trial will enroll those diagnosed with pediatric brain cancer and healthy children with the genetic trait. We have collected samples in collaboration with Children’s National Hospital. These will be evaluated on our REDN Discovery chips to identify NF-1 cancer-specific neoantigens.

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Contact Us

Please direct any questions or comments you have for us via our contact form below.

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850 N. 5th Street Phoenix, AZ

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